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Continuous deacylation of amides in a high-temperature and high-pressure microreactor

《化学科学与工程前沿（英文）》 2022年第16卷第12期页码 1818-1825 doi: 10.1007/s11705-022-2182-y

摘要： The deacylation of amides, which is widely employed in the pharmaceutical industry, is not a fast reaction under normal conditions. To intensify this reaction, a high-temperature and high-pressure continuous microreaction technology was developed, whose space-time yield was 49.4 times that of traditional batch reactions. Using the deacylation of acetanilide as a model reaction, the effects of the temperature, pressure, reaction time, molar ratio of reactants, and water composition on acetanilide conversion were carefully studied. Based on the rapid heating and cooling capabilities, the kinetics of acetanilide deacylation at high temperatures were investigated to determine the orders of reactants and activation energy. This microreaction technology was further applied to a variety of other amides to understand the influence of substituents and steric hindrance on the deacylation reaction.

关键词： amide deacylation microreactor flow chemistry reaction intensification

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Ultrasonic emulsification: basic characteristics, cavitation, mechanism, devices and application

《化学科学与工程前沿（英文）》 2023年第17卷第10期页码 1560-1583 doi: 10.1007/s11705-022-2160-4

摘要： Emulsion systems are widely applied in agriculture, food, cosmetic, pharmaceutical and biomedical industries. Ultrasound has attracted much attention in emulsion preparation, especially for nanoemulsion, due to its advantages of being eco-friendly, cost-effective and energy-efficient. This review provides an overview for readers to the area of ultrasonic emulsification technology. It briefly introduces and summarizes knowledge of ultrasonic emulsification, including emulsion characteristics, acoustic cavitation, emulsification mechanism, ultrasonic devices and applications. The combination of microfluidics and ultrasound is highlighted with huge advantages in controlling cavitation phenomena and emulsification intensification. A novel scale of dμ_C^0.6/μ_D^0.33−E_V is proposed to be able to compare the energy efficiency of emulsion preparation in different devices.

关键词： nanoemulsion ultrasound microreactor multiphase energy

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电化学微反应技术的工程研究进展——一种新型有机化合物电合成方法 Review

郑思源, 闫俊妤, 王凯

《工程（英文）》 2021年第7卷第1期页码 22-32 doi: 10.1016/j.eng.2020.06.025

摘要：

电化学方法环境友好，在有机化学合成中具有独特的优势。然而，传统的电化学反应器存在复杂的传递问题，限制了电化学方法的应用。近年来，微反应技术在电合成研究中的应用缩短了离子的传递距离并增加了电极的比表面积，从而促成了高效、连续且易于规模化的电合成技术。本文从过程强化的角度讨论了在电合成中使用微通道的工程优势，分析了最近报道的电化学微反应器中的流型和传质行为，并列举了反应器放大的典型例子。作为一个相对较新的研究领域，在微反应器中进行电合成的许多科学规则和工程特征都有待研究。因此本文提出了潜在的研究重点，认为其对新型电合成技术的发展至关重要。

关键词：电化学电合成微反应器流动化学